Erickson Lori A, Highsmith W Edward, Fei Peiwen, Zhang Jun
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI, USA.
Drug Des Devel Ther. 2015 Apr 8;9:2029-31. doi: 10.2147/DDDT.S80888. eCollection 2015.
The correlation between hypoxia and pancreatic cancer has long been discussed. Hao's research team made many efforts on revealing the oncogenic function of hypoxic inducible factor-1 (HIF-1) in pancreatic cancer progression and development in recent years. Based on their research, they linked micro-environmental regulation of pancreatic cancer and its clinical significance. Hao's research team suggests it is a promising approach to target HIF-1 for the management of pancreatic cancer progression and invasion.
缺氧与胰腺癌之间的相关性长期以来一直被讨论。近年来，郝的研究团队在揭示缺氧诱导因子-1（HIF-1）在胰腺癌进展和发展中的致癌功能方面做出了诸多努力。基于他们的研究，他们将胰腺癌的微环境调节与其临床意义联系起来。郝的研究团队表明，针对HIF-1来控制胰腺癌的进展和侵袭是一种很有前景的方法。
