Snyder J J, Salkowski N, Wey A, Israni A K, Schold J D, Segev D L, Kasiske B L
Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN.
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Am J Transplant. 2016 Sep;16(9):2646-53. doi: 10.1111/ajt.13783. Epub 2016 Apr 5.
There is a perception that transplanting high-risk kidneys causes programs to be identified as underperforming, thereby increasing the frequency of discards and diminishing access to transplant. Thus, the Organ Procurement and Transplantation Network (OPTN) has considered excluding transplants using kidneys from donors with high Kidney Donor Profile Index (KDPI) scores (≥0.85) when assessing program performance. We examined whether accepting high-risk kidneys (KDPI ≥0.85) for transplant yields worse outcome evaluations. Despite a clear relationship between KDPI and graft failure and mortality, there was no relationship between a program's use of high-KDPI kidneys and poor performance evaluations after risk adjustment. Excluding high-KDPI donor transplants from the June 2015 evaluations did not alter the programs identified as underperforming, because in every case underperforming programs also had worse-than-expected outcomes among lower-risk donor transplants. Finally, we found that hypothetically accepting and transplanting additional kidneys with KDPI similar to that of kidneys currently discarded would not adversely affect program evaluations. Based on the study findings, there is no evidence that programs that accept higher-KDPI kidneys are at greater risk for low performance evaluations, and risk aversion may limit access to transplant for candidates while providing no measurable benefit to program evaluations.
有一种观点认为,移植高风险肾脏会导致项目被认定为表现不佳,从而增加丢弃率并减少移植机会。因此,器官获取与移植网络(OPTN)在评估项目表现时,曾考虑排除使用肾脏捐赠者风险评估指数(KDPI)得分较高(≥0.85)的肾脏进行的移植。我们研究了接受高风险肾脏(KDPI≥0.85)进行移植是否会产生更差的结果评估。尽管KDPI与移植物失败和死亡率之间存在明确关系,但在风险调整后,项目使用高KDPI肾脏与不良表现评估之间并无关联。在2015年6月的评估中排除高KDPI捐赠者的移植,并未改变被认定为表现不佳的项目,因为在每种情况下,表现不佳的项目在低风险捐赠者移植中的结果也比预期更差。最后,我们发现,假设接受并移植额外的与目前被丢弃肾脏KDPI相似的肾脏,不会对项目评估产生不利影响。基于研究结果,没有证据表明接受更高KDPI肾脏的项目在低表现评估方面面临更大风险,而规避风险可能会限制候选者的移植机会,同时对项目评估没有可衡量的益处。