荧光素钠引导下的恶性脑肿瘤手术：历史、当前概念及未来规划
Fluorescein Sodium-Guided Surgery of Malignant Brain Tumors: History, Current Concepts, and Future Project.
作者信息
Schebesch Karl-Michael, Brawanski Alexander, Hohenberger Christoph, Hohne Julius
机构信息
University Medical Center Regensburg, Department of Neurosurgery, Germany.
出版信息
Turk Neurosurg. 2016;26(2):185-94. doi: 10.5137/1019-5149.JTN.16952-16.0.
Fluorescein sodium (FL)-guided resection has become an important and beneficial treatment method for malignant brain tumors. FL-guided resection improves the rate of gross total resection in high-grade gliomas (HGG) and cerebral metastases (CM). FL sensitively visualizes the disruption of the blood-brain barrier in the area surrounding malignant lesions, similar to contrast-enhanced T1-weighted MR sequences. This review of the current literature summarizes the history of FL in neurosurgery from 1946 until today. We discuss the molecular mechanism of FL accumulation in cerebral malignant tumors and provide an overview of the current practice of using FL and applying a dedicated surgical microscope filter. Additionally, we outline and discuss ongoing trials and future projects.
荧光素钠（FL）引导下的切除术已成为恶性脑肿瘤的一种重要且有益的治疗方法。FL引导下的切除术提高了高级别胶质瘤（HGG）和脑转移瘤（CM）的全切除率。与增强T1加权磁共振序列类似，FL能灵敏地显示恶性病变周围区域血脑屏障的破坏情况。本文对当前文献的综述总结了1946年至今FL在神经外科的应用历史。我们讨论了FL在脑恶性肿瘤中蓄积的分子机制，并概述了目前使用FL及应用专用手术显微镜滤光片的实践情况。此外，我们还概述并讨论了正在进行的试验和未来项目。
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