Tan Audrey J L, Tey Min Li, Seow Wan Tew, Low David C Y, Chang Kenneth T E, Ng Lee Ping, Looi Wen Shen, Wong Ru Xin, Tan Enrica E K, Low Sharon Y Y
Department of Neurosurgery, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.
Neurosurgical Service, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore.
NeuroSci. 2023 Feb 13;4(1):54-64. doi: 10.3390/neurosci4010007. eCollection 2023 Mar.
(1) Background: Fluorescein sodium (Na-Fl) has been described as a safe and useful neurosurgical adjunct in adult neurooncology. However, its use has yet to be fully established in children. We designed a study to investigate the use of intraoperative Na-Fl in pediatric brain tumor surgery. (2) Methods: This is a single-institution study for pediatric brain tumor patients managed by the Neurosurgical Service, KK Women's and Children's Hospital. Inclusion criteria consists of patients undergoing surgery for suspected brain tumors from 3 to 19 years old. A predefined intravenous dose of 2 mg/kg of 10% Na-Fl is administered per patient. Following craniotomy, surgery is performed under alternating white light and YELLOW-560 nm filter illumination. (3) Results: A total of 21 patients with suspected brain tumours were included. Median age was 12.1 years old. For three patients (14.3%), there was no significant Na-Fl fluorescence detected and their final histologies reported a cavernoma and two radiation-induced high grade gliomas. The remaining patients (85.7%) had adequate intraoperative fluorescence for their lesions. No adverse side effects were encountered with the use of Na-Fl. (4) Conclusions: Preliminary findings demonstrate the safe and efficacious use of intraoperative Na-Fl for brain tumors as a neurosurgical adjunct in our pediatric patients.
(1) 背景：荧光素钠（Na-Fl）在成人神经肿瘤学中已被描述为一种安全且有用的神经外科辅助药物。然而，其在儿童中的应用尚未完全确立。我们设计了一项研究来调查术中Na-Fl在小儿脑肿瘤手术中的应用。(2) 方法：这是一项在KK妇女儿童医院神经外科进行的针对小儿脑肿瘤患者的单机构研究。纳入标准包括3至19岁疑似脑肿瘤接受手术的患者。每位患者预先静脉注射2mg/kg的10% Na-Fl。开颅术后，手术在交替的白光和560nm黄色滤光片照明下进行。(3) 结果：共纳入21例疑似脑肿瘤患者。中位年龄为12.1岁。3例患者（14.3%）未检测到明显的Na-Fl荧光，其最终组织病理学报告为海绵状血管瘤和2例放射性诱导的高级别胶质瘤。其余患者（85.7%）术中病变荧光充足。使用Na-Fl未出现不良副作用。(4) 结论：初步研究结果表明，术中Na-Fl作为神经外科辅助药物在我们的小儿患者脑肿瘤手术中安全有效。
