Pujol C, Febrer I, Peydro A, Carda C, Valcuende F, Castells A, Grau M, Millan F, Aliaga A
Departamento de Dermatología, Hospital Clínico. Valencia.
Med Cutan Ibero Lat Am. 1989;17(5):326-31.
Oral hairy leukoplakia (HL) is a newly described lesion (1984) in human immunodeficiency virus infected patients. Patients with HL show a high probability of developing an acquired immunodeficiency syndrome (AIDS). The results of histopathological, microbiological, immunological and ultrastructural studies in five patients with HL and AIDS are reported. The histopathological exam revealed in all cases acanthosis, parakeratosis, koilocytosis and keratin projections on the surface. Dermis was normal. Herpes type virus were seen in four cases and in one of them papilloma virus was also present in electron microscopic examination. There was immunocytochemical evidence of papilloma virus in one lesion. Candida albicans was found in 5 lesions by culture but only in two ones by periodic acid Schiff stain. Virus cultures for herpes virus were negative. Immunocytochemical search of Langerhans cells (S-100, HLA-DR, OKT4, OKT6) showed nearly absence of these cells in HL lesions. These results favour the viral etiology hypothesis of hairy leukoplakia.
口腔毛状白斑（HL）是1984年新描述的人类免疫缺陷病毒感染患者的一种病变。HL患者发生获得性免疫缺陷综合征（AIDS）的可能性很高。本文报告了5例HL合并AIDS患者的组织病理学、微生物学、免疫学及超微结构研究结果。组织病理学检查显示，所有病例均有棘层肥厚、角化不全、空泡细胞及表面角质突起。真皮正常。4例可见疱疹病毒，其中1例在电镜检查中还发现乳头瘤病毒。1个病变中有乳头瘤病毒的免疫细胞化学证据。通过培养在5个病变中发现白色念珠菌，但经高碘酸希夫染色仅在2个病变中发现。疱疹病毒的病毒培养结果为阴性。对朗格汉斯细胞（S-100、HLA-DR、OKT4、OKT6）进行免疫细胞化学检测显示，HL病变中几乎不存在这些细胞。这些结果支持毛状白斑的病毒病因假说。
