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吡唑及其生物活性的当前状况。

Current status of pyrazole and its biological activities.

作者信息

Naim Mohd Javed, Alam Ozair, Nawaz Farah, Alam Md Jahangir, Alam Perwaiz

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Shree Ganpati Institute of Technology, Ghaziabad, Uttar Pradesh, India.

出版信息

J Pharm Bioallied Sci. 2016 Jan-Mar;8(1):2-17. doi: 10.4103/0975-7406.171694.

DOI:10.4103/0975-7406.171694
PMID:26957862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4766773/
Abstract

Pyrazole are potent medicinal scaffolds and exhibit a full spectrum of biological activities. This review throws light on the detailed synthetic approaches which have been applied for the synthesis of pyrazole. This has been followed by an in depth analysis of the pyrazole with respect to their medical significance. This follow-up may help the medicinal chemists to generate new leads possessing pyrazole nucleus with high efficacy.

摘要

吡唑是有效的药用骨架，具有全方位的生物活性。本综述阐述了已应用于吡唑合成的详细合成方法。随后对吡唑的医学意义进行了深入分析。这后续研究可能有助于药物化学家生成具有高效能的含吡唑核的新先导化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f6/4766773/27226bd6b339/JPBS-8-2-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f6/4766773/10e924db209a/JPBS-8-2-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f6/4766773/57c070470e93/JPBS-8-2-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f6/4766773/2afb3b83e300/JPBS-8-2-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f6/4766773/50b91e04f266/JPBS-8-2-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f6/4766773/a729d3976d57/JPBS-8-2-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f6/4766773/79b85c575e72/JPBS-8-2-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f6/4766773/15c086afbf4e/JPBS-8-2-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f6/4766773/50b91e04f266/JPBS-8-2-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f6/4766773/79b85c575e72/JPBS-8-2-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f6/4766773/15c086afbf4e/JPBS-8-2-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14f6/4766773/4895ef461da0/JPBS-8-2-g011.jpg
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