Gallet S, Bellon G
Clinique médicale infantile, Centre Hospitalier Lyon-Sud, France.
Pediatrie. 1989;44(9):699-704.
Primary tuberculosis should be treated in all cases. In adults, the total treatment course for pulmonary tuberculosis can be shortened to 6 months. If the disease is not symptomatic, the rifampicin-isoniazid combination (10 mg/kg/day each) appears to be preferable to single drug therapy. In patients with symptomatic disease, pyrazinamide (30 mg/kg/day) should be added during the first 6-8 weeks and in some cases, corticosteroid therapy is also required. The drugs are usually well tolerated, but hepatic function should be monitored.
所有原发性肺结核病例均应接受治疗。对于成年人，肺结核的总疗程可缩短至6个月。如果疾病没有症状，利福平-异烟肼联合用药（各10毫克/千克/天）似乎比单一药物治疗更可取。对于有症状的患者，在前6-8周应加用吡嗪酰胺（30毫克/千克/天），在某些情况下，还需要进行皮质类固醇治疗。这些药物通常耐受性良好，但应监测肝功能。
