Batarseh Yazan S, Duong Quoc-Viet, Mousa Youssef M, Al Rihani Sweilem B, Elfakhri Khaled, Kaddoumi Amal
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 70504, USA.
Int J Mol Sci. 2016 Mar 4;17(3):338. doi: 10.3390/ijms17030338.
Amyloid-β (Aβ) pathology is known to promote chronic inflammatory responses in the brain. It was thought previously that Aβ is only associated with Alzheimer's disease and Down syndrome. However, studies have shown its involvement in many other neurological disorders. The role of astrocytes in handling the excess levels of Aβ has been highlighted in the literature. Astrocytes have a distinctive function in both neuronal support and protection, thus its involvement in Aβ pathological process may tip the balance toward chronic inflammation and neuronal death. In this review we describe the involvement of astrocytes in Aβ related disorders including Alzheimer's disease, Down syndrome, cerebral amyloid angiopathy, and frontotemporal dementia.
已知β淀粉样蛋白（Aβ）病理会促进大脑中的慢性炎症反应。以前人们认为Aβ仅与阿尔茨海默病和唐氏综合征有关。然而，研究表明它还参与许多其他神经疾病。星形胶质细胞在处理过量Aβ水平方面的作用已在文献中得到强调。星形胶质细胞在神经元支持和保护方面具有独特功能，因此其参与Aβ病理过程可能会使平衡倾向于慢性炎症和神经元死亡。在本综述中，我们描述了星形胶质细胞在与Aβ相关的疾病中的作用，包括阿尔茨海默病、唐氏综合征、脑淀粉样血管病和额颞叶痴呆。
