Fuller R W
Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Postgrad Med J. 1989;65 Suppl 1:S58-60.
Angiotensin converting enzyme inhibitors are effective hypotensive agents, lowering blood pressure in patients with mild to moderate hypertension either alone or in combination with a low dose loop diuretic. They are generally well tolerated and score well in quality of life studies. However, in some patients they do cause cough, which may lead to their withdrawal, and their association with renal failure and death in elderly patients may reduce their usefulness in this age group. Nevertheless they have established a role as first line therapy in patients with asthma and diabetes.
血管紧张素转换酶抑制剂是有效的降压药物，可单独或与低剂量袢利尿剂联合使用，降低轻至中度高血压患者的血压。它们通常耐受性良好，在生活质量研究中得分较高。然而，在一些患者中，它们确实会引起咳嗽，这可能导致停药，而且它们与老年患者的肾衰竭和死亡有关，这可能会降低它们在该年龄组中的效用。尽管如此，它们已成为哮喘和糖尿病患者一线治疗药物。
