[接受维替泊芬光动力治疗患者的角膜新生血管消退情况]

[Neovascularization corneal regression in patients treated with photodynamic therapy with verteporfin].

作者信息

Díaz-Dávalos César David, Carrasco-Quiroz Arturo, Rivera-Díez Dirce

机构信息

División de Oftalmología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México,

出版信息

Rev Med Inst Mex Seguro Soc. 2016 Mar-Apr;54(2):164-9.

PMID:26960043

Abstract

BACKGROUND

Corneal neovascularization is a vision-threatening condition usually associated with inflammatory or infectious disorders of the ocular surface. One current treatment is photodynamic therapy, which uses a photosensitizer to occlude the vessel, is successfully produced microvascular thrombosis with minimal damage to surrounding normal tissue. The aim of this article is to quantitatively determine the percentage of regression of corneal neovascularization experienced by patients treated with photodynamic therapy with verteporfin.

METHODS

A before and after treatment; experimental, analytical, prospective and longitudinal.

RESULTS

Of the 25 new vessels analyzed, 8 glasses (32 %) had total occlusion one month after, 15 vessels (60 %) had a partial occlusion in the range of 15.3 to 85.1 %, and 2 vessels (8 %) worsening in corneal vascularization. The mean area of corneal neovascularization decreased significantly a 70 % from 0.147 ± 0.118 mm2 to 0.045 ± 0.046 mm2 (p < 0.0005) after photodynamic therapy. No side efects were reported.

CONCLUSIONS

Photodynamic therapy with verteporfin is a safe and effective method of reducing corneal neovascularization and can be used to inhibit angiogenesis in the cornea.

摘要

背景

角膜新生血管形成是一种威胁视力的疾病，通常与眼表的炎症或感染性疾病相关。目前的一种治疗方法是光动力疗法，该方法使用一种光敏剂来阻塞血管，已成功产生微血管血栓形成，对周围正常组织的损伤最小。本文的目的是定量确定接受维替泊芬光动力疗法治疗的患者角膜新生血管消退的百分比。

方法

治疗前后对照；实验性、分析性、前瞻性和纵向研究。

结果

在分析的25条新生血管中，8条血管（32%）在1个月后完全闭塞，15条血管（60%）部分闭塞，闭塞范围在15.3%至85.1%之间，2条血管（8%）角膜血管化加重。光动力疗法后，角膜新生血管的平均面积从0.147±0.118平方毫米显著减少70%至0.045±0.046平方毫米（p<0.0005）。未报告副作用。