华法林治疗的深静脉血栓患者国际标准化比值低于或高于范围时处方者的行为。

Prescribers' behavior following below- versus above-range international normalized ratio values in warfarin-treated deep vein thrombosis patients.

作者信息

Raut Monika K, Nelson Winnie W, Wang Sheng-Wei, Coleman Craig I, Lu Lang, Patel Dhaval, Schein Jeff R, Xiang Jim, Damaraju C V

机构信息

a Janssen Scientific Affairs LLC , Raritan , NJ , USA ;

b Janssen Research and Development LLC , Raritan , NJ , USA ;

出版信息

Curr Med Res Opin. 2016 Jul;32(7):1213-5. doi: 10.1185/03007995.2016.1164678. Epub 2016 Mar 17.

DOI:10.1185/03007995.2016.1164678

PMID:26960249

Abstract

Maintaining acceptable international normalized ratio (INR) control among deep vein thrombosis (DVT) patients taking warfarin is challenging. We evaluated prescribers' behavior to out-of-range INRs in DVT patients following initial INR stabilization. Following INR stabilization, a below-range INR was associated with fewer subsequent measurements and warfarin-dosing adjustments, and a longer time to re-achieve a therapeutic INR compared to an above-range INR.

摘要

在服用华法林的深静脉血栓形成（DVT）患者中维持可接受的国际标准化比值（INR）控制具有挑战性。我们评估了初始INR稳定后，处方医生对DVT患者INR超出范围的处理行为。INR稳定后，与INR超出范围相比，INR低于范围与后续测量及华法林剂量调整次数减少有关，且重新达到治疗性INR的时间更长。