Temiz-Arpaci Ozlem, Doğanc Fatma, Sac Duygu, Sari Elmas, Kaynak-Onurdag Fatma, Okten Suzan
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara University , 06100, Tandogan, Ankara , Turkey.
Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Trakya University , 22030, Edirne , Turkey.
Acta Biol Hung. 2016 Mar;67(1):75-84. doi: 10.1556/018.67.2016.1.6.
A series of 2-(p-substituted phenyl)-5-[(4-substituted phenyl) sulfonylamido]-benzoxazoles were synthesized and tested for their antimicrobial activities. The structures of the new derivatives were elucidated by spectral techniques. The minimum inhibitory concentrations (MIC) of the new benzoxazoles were determined against standard bacterial and fungal strains and drug-resistant isolates and compared to those of several reference drugs.
合成了一系列2-(对-取代苯基)-5-[(4-取代苯基)磺酰氨基]-苯并恶唑，并对其抗菌活性进行了测试。通过光谱技术阐明了新衍生物的结构。测定了新苯并恶唑对标准细菌和真菌菌株以及耐药分离株的最低抑菌浓度(MIC)，并与几种参考药物的MIC进行了比较。
