Rallabandi Hima Bindu, Swain Meenakshi, Gowrishankar Swarnalata, Sinha Sanjay
Department of Histopathology, Apollo Hospital, Hyderabad, Telangana, India.
Indian J Pathol Microbiol. 2016 Jan-Mar;59(1):78-80. doi: 10.4103/0377-4929.178234.
Angiosarcomas are rare soft tissue neoplasms accounting for <2% of all sarcomas. Rare cases have been reported in other sites like breast, spleen, liver, bone and bladder. This is a case report of an angiosarcoma of the bladder in a 65 year old lady who came with complaints of haematuria. Ultrasonography and computerized tomography revealed a bladder tumour with calcification, which on cystoscopy also showed a calcified mass. The patient had a past history of carcinoma cervix for which she had undergone surgery and radiotherapy, 22 years ago. Biopsy of the bladder mass showed features of a high grade epithelioid sarcoma with extensive osseous metaplasia. On immune stains,the tumour was positive for CD31 and vimentin and negative for cytokeratin, desmin and CD34. Until now, only sixteen cases of angiosarcoma of the bladder have been reported in english literature, of which 6 occurred secondary to radiation. Our case is the first to occur after 22 years of radiotherapy and have extensive osseous metaplasia.
血管肉瘤是罕见的软组织肿瘤，占所有肉瘤的比例不到2%。其他部位如乳腺、脾脏、肝脏、骨骼和膀胱也有罕见病例报道。本文报告一例65岁女性膀胱血管肉瘤病例，该患者因血尿前来就诊。超声检查和计算机断层扫描显示膀胱肿瘤伴有钙化，膀胱镜检查也显示为钙化肿块。该患者有子宫颈癌病史，22年前接受过手术和放疗。膀胱肿块活检显示为高级别上皮样肉瘤，伴有广泛的骨化生。免疫组化染色显示，肿瘤CD31和波形蛋白呈阳性，细胞角蛋白、结蛋白和CD34呈阴性。截至目前，英文文献中仅报道了16例膀胱血管肉瘤病例，其中6例继发于放疗。我们的病例是放疗22年后发生的首例病例，且伴有广泛的骨化生。
