Department of Radiology, Body MRI, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.
Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, 10029, USA.
Abdom Radiol (NY). 2016 Jul;41(7):1300-9. doi: 10.1007/s00261-016-0693-z.
To compare MRI using gadobenate dimeglumine (Gd-BOPTA) vs. gadoxetic acid disodium (Gd-EOB-DTPA) for the assessment of biliary anatomy of potential liver donors.
76 potential liver donors (39 M/37 F, mean 38 years) who underwent 1.5T MRI using Gd-BOPTA (n = 37) or Gd-EOB-DTPA (n = 39) were retrospectively evaluated. T2 cholangiogram (T2 MRC) and delayed hepatobiliary phase (HBP) T1 cholangiogram (T1 MRC) (performed during HBP 20 min after injection of Gd-EOB-DTPA and 1-2 h after Gd-BOPTA injection) were obtained in addition to MR angiogram/venogram. Two independent observers evaluated image quality (IQ) and conspicuity scores (CS) of the biliary system. Biliary anatomy was assessed in 3 reading sessions (T2 MRC, T1 MRC, and combined T2/T1 MRC). Reference standard consisted of consensus reading of two separate observers of all image sets, clinical/surgical information and intraoperative cholangiogram when available. Datasets were compared using the Mann-Whitney U test or Chi-squared test.
There was no difference in IQ for T1 MRC using either contrast agent or T2 MRC vs. T1 MRC for both observers (all p values >0.07). There was superior CS for T2 MRC vs. Gd-BOPTA T1 MRC for both observers and T2 MRC vs. Gd-EOB for one observer (p < 0.001). No difference was found for biliary variant detection for T1 MRC (with either contrast agent) vs. T2 MRC. Combined T2/T1 MRC demonstrated improved sensitivity for biliary variant detection using Gd-BOPTA for both observers (p < 0.004) and Gd-EOB-DTPA for one observer (p < 0.001).
Equivalent image quality was found for T1 MRC obtained with Gd-BOPTA or Gd-EOB-DTPA and T2 MRC. T1 MRC is equivalent to T2 MRC for detection of variant biliary anatomy, and the combination of sequences may have added value.
比较使用钆贝葡胺（Gd-BOPTA）与钆塞酸二钠（Gd-EOB-DTPA）的 MRI 对潜在肝供体胆道解剖结构的评估。
回顾性分析 76 例潜在肝供体（39 例男性/37 例女性，平均 38 岁），他们分别接受了使用 Gd-BOPTA（n=37）或 Gd-EOB-DTPA（n=39）的 1.5T MRI 检查。除了磁共振血管造影/静脉造影外，还获得了 T2 胆管造影（T2 MRC）和延迟肝胆期（HBP）T1 胆管造影（T1 MRC）（在注射 Gd-EOB-DTPA 后 20 分钟的 HBP 期间和 Gd-BOPTA 注射后 1-2 小时获得）。两名独立的观察者评估了胆道系统的图像质量（IQ）和明显度评分（CS）。胆道解剖结构在 3 次阅读会议（T2 MRC、T1 MRC 和 T2/T1 MRC 联合）中进行评估。参考标准包括对所有图像集的两位独立观察者的共识阅读、临床/手术信息和有条件时的术中胆管造影。使用 Mann-Whitney U 检验或卡方检验比较数据集。
对于 T1 MRC，使用任何一种对比剂的观察者 1 和观察者 2 的 IQ 均无差异（所有 p 值均>0.07）。观察者 1 和观察者 2 的 T2 MRC 的 CS 均优于 Gd-BOPTA T1 MRC，观察者 1 的 T2 MRC 的 CS 也优于 Gd-EOB（p<0.001）。对于 T1 MRC（使用任何一种对比剂）与 T2 MRC 相比，胆道变异的检出率无差异。对于 Gd-BOPTA，观察者 1 和观察者 2 的 T2/T1 MRC 联合显示出对胆道变异检测的敏感性提高（p<0.004）；对于 Gd-EOB-DTPA，观察者 1 的敏感性提高（p<0.001）。
使用 Gd-BOPTA 或 Gd-EOB-DTPA 获得的 T1 MRC 与 T2 MRC 的图像质量相当。T1 MRC 与 T2 MRC 一样可以检测到胆道解剖结构的变异，序列的联合可能具有附加价值。
