Cao Can, Yan Jun, Zhang Yumei, Zhao Lingzhou
State key Laboratory of Military Stomatology, Department of Prosthetic Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.
Department of Stomatology, General Hospital of Shenyang military region Command, China.
Sci Rep. 2016 Mar 10;6:23065. doi: 10.1038/srep23065.
Titania nanotube arrays (NTAs) on titanium (Ti) fabricated by electrochemical anodization have attracted tremendous interest for diverse applications, of which most perform in aqueous environment or related to interaction with water. The NTAs are widely studied however the related factor of stability of NTAs when applied in such environment has rarely been concerned. We report that the annealed anatase NTAs are stable but the non-annealed amorphous NTAs are unstable to undergo specific structural change accompanied with a process of amorphous TiO2 dissolution and anatase TiO2 recrystallization. Quite unexpectedly, the non-annealed NTAs still show good stability without structural change in the cell culture media, possibly due to the presence of inorganics that may interfere with the TiO2 dissolution/redeposition process. The pH value of the aqueous environment is not a determinant factor for the structural change for non-annealed NTAs or not, while the temperature and the existence of F(-) can accelerate the structural change process. F(-) may play a very important role in the change process.
通过电化学阳极氧化法在钛（Ti）上制备的二氧化钛纳米管阵列（NTAs）因其多样的应用而备受关注，其中大多数应用于水环境或与水的相互作用。NTAs得到了广泛研究，然而，在这种环境中应用时，NTAs稳定性的相关因素却很少受到关注。我们报道，退火后的锐钛矿型NTAs是稳定的，但未退火的非晶态NTAs不稳定，会发生特定的结构变化，伴随着非晶态TiO₂溶解和锐钛矿型TiO₂再结晶的过程。非常出乎意料的是，未退火的NTAs在细胞培养基中仍表现出良好的稳定性，且无结构变化，这可能是由于存在可能干扰TiO₂溶解/再沉积过程的无机物。水环境的pH值并非未退火NTAs结构变化与否 的决定性因素，而温度和F⁻的存在会加速结构变化过程。F⁻可能在变化过程中起非常重要的作用。
