用于恶性疟原虫和间日疟原虫的蛋白酶体-疏水“足”疟疾肽疫苗。

Proteosome-hydrophobic 'foot' malaria peptide vaccines for Plasmodium falciparum and P. vivax.

作者信息

Lowell G H, Ballou W R, Smith L F, Zollinger W D, Hockmeyer W T

机构信息

Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, DC 20307-5100.

出版信息

Trans R Soc Trop Med Hyg. 1989;83 Suppl:101-2. doi: 10.1016/0035-9203(89)90614-7.

DOI:10.1016/0035-9203(89)90614-7

PMID:2696152

Abstract

The immunogenicity of synthetic peptides representing the repeating portions of circumsporozoite proteins of Plasmodium sporozoites was greatly increased by complexing them to proteosomes via hydrophobic moieties added to their amino termini. Proteosomes have been used safely in people in the development of meningococcal vaccines and therefore proteosome-peptide vaccines are prime candidates for use against malaria.

摘要

通过将代表疟原虫子孢子环子孢子蛋白重复部分的合成肽与通过添加到其氨基末端的疏水部分与蛋白酶体复合，其免疫原性大大提高。蛋白酶体已在人用脑膜炎球菌疫苗的研发中安全使用，因此蛋白酶体-肽疫苗是抗疟疾疫苗的主要候选者。