Zhang Bingru, Kitzerow Heinz-S
Department of Chemistry, University of Paderborn , Warburger Strasse 100, 33098 Paderborn, Germany.
J Phys Chem B. 2016 Mar 31;120(12):3250-6. doi: 10.1021/acs.jpcb.6b01644. Epub 2016 Mar 21.
Lyotropic chromonic liquid crystals have recently been suggested for use as a self-organized host for dispersing and aligning self-organized DNA origami nanostructures. However, an appropriate pH value and a suitable cation concentration are necessary to stabilize such nanostructures and to avoid unfolding of the DNA. The present study shows that the nematic and columnar liquid crystal phases appearing in aqueous solutions of disodium cromoglycate are robust against the replacement of deionized water by a neutral or alkaline buffer solution. However, disodium cromoglycate precipitates when an acidic buffer is used or when the concentration of magnesium cations exceeds a critical concentration of about 0.6-0.7 mmol/L.
溶致变色液晶最近被提议用作一种自组装主体，用于分散和排列自组装的DNA折纸纳米结构。然而，需要合适的pH值和适宜的阳离子浓度来稳定此类纳米结构，并避免DNA解折叠。本研究表明，色甘酸钠水溶液中出现的向列相和柱状液晶相对用中性或碱性缓冲溶液替代去离子水具有抗性。然而，当使用酸性缓冲液或镁阳离子浓度超过约0.6 - 0.7 mmol/L的临界浓度时，色甘酸钠会沉淀。
