Brauner R, Rappaport R
Ann Pediatr (Paris). 1989 Dec;36(10):653-8.
Diagnosis of the central origin of precocious puberty is easy in boys on the enlargement of the testes. In girls, conversely, diagnosis of central precocious puberty (CPP) may be difficult, as isolated development of the breast may initially be the only feature. Differentiation of CPP and premature thelarche is nevertheless essential, as CPP always requires neuroradiologic investigations to look for an intracranial space-occupying lesion and may indicate inhibitory treatment. CPP is usually idiopathic in girls and tumor-related in boys. Early secretion of sex steroids increases the rate of growth and bone maturation and may lead to final short stature. LHRH analogues represent a breakthrough in the treatment of CPP.
对于男孩,性早熟的中枢性起源诊断较容易,因为睾丸增大即可判断。相反,对于女孩,中枢性性早熟(CPP)的诊断可能较为困难,因为最初可能仅表现为乳房孤立性发育。然而,区分CPP和单纯性乳房早发育至关重要,因为CPP总是需要进行神经放射学检查以寻找颅内占位性病变,并且可能需要进行抑制性治疗。女孩的CPP通常为特发性,而男孩则与肿瘤相关。性类固醇的过早分泌会加快生长速度和骨骼成熟,可能导致最终身材矮小。促性腺激素释放激素(LHRH)类似物是CPP治疗的一项突破。