Mu Weiyun, Yao Weijuan
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2015 Oct;32(5):1141-5.
Hematopoietic stem cells (HSCs) are tissue specific stem cells that replenish all mature blood lineages during the lifetime of an individual. Hematopoietic cell clusters in the aorta of vertebrate embryos play a pivotal role in the formation of the adult blood system. Recently, people have learned a lot about the embryonic HSCs on their development and homing. During their differentiation, HSCs are regulated by the transcription factors, such as Runx1 and Notch signaling pathway, etc. MicroRNAs also regulate the self-renewal and differentiation of hematopoietic stem/progenitor cells on the post-transcriptional levels. Since the onset of circulation, the formation of HSCs and their differentiation into blood cells, especially red blood cells, are regulated by the hemodynamic forces. It would be of great significance if we could treat hematologic diseases with induced HSCs in vitro on the basis of fully understanding of hemotopoietic stem cell development. This review is focused on the advances in the research of HSCs' development and regulation.
造血干细胞（HSCs）是组织特异性干细胞，在个体一生中补充所有成熟的血细胞谱系。脊椎动物胚胎主动脉中的造血细胞簇在成体血液系统的形成中起关键作用。最近，人们对胚胎造血干细胞的发育和归巢有了很多了解。在造血干细胞分化过程中，它们受到转录因子如Runx1和Notch信号通路等的调控。微小RNA也在转录后水平调节造血干/祖细胞的自我更新和分化。自血液循环开始以来，造血干细胞的形成及其向血细胞尤其是红细胞的分化受血流动力学力的调节。如果我们能在充分了解造血干细胞发育的基础上，在体外诱导造血干细胞来治疗血液系统疾病，那将具有重要意义。本综述聚焦于造血干细胞发育和调控研究的进展。
