Wales J K, Milner R D
Department of Paediatrics, Sheffield University Children's Hospital.
Arch Dis Child. 1989 Dec;64(12):1708-12. doi: 10.1136/adc.64.12.1708.
Knemometry has been used in a short term double blind placebo controlled trial in 13 patients with normal variant short stature receiving treatment with somatropin to assess the power of the change in lower leg velocity at one month to predict the increase in height velocity at six months. Used in this way the method has a positive predictive value and sensitivity of 90% and a negative predictive value and specificity of 50%. Although not a perfect discriminatory test, knemometry is a more reliable and less invasive way of analysing the likely value of a growth promoting treatment than metabolic assays in individual patients. Given the possible future rapid expansion of the use of somatropin in short stature of various aetiologies there is a need for a relatively simple and inexpensive means of evaluating response to treatment.
在一项短期双盲安慰剂对照试验中，对13名身材矮小但正常变异且接受生长激素治疗的患者使用了小腿测量法，以评估一个月时小腿速度变化预测六个月时身高速度增加的能力。以这种方式使用该方法时，其阳性预测值和敏感性为90%，阴性预测值和特异性为50%。虽然不是一个完美的鉴别测试，但与个体患者的代谢检测相比，小腿测量法是一种更可靠且侵入性更小的分析生长促进治疗可能价值的方法。鉴于未来生长激素在各种病因导致的身材矮小中的使用可能会迅速扩大，需要一种相对简单且廉价的方法来评估治疗反应。
