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[低强度900兆赫频率电磁辐射对大鼠脑内与能量代谢相关酶活性的影响]

[Effect of Low-Intensity 900 MHz Frequency Electromagnetic Radiation on Rat Brain Enzyme Activities Linked to Energy Metabolism].

作者信息

Petrosyan M S, Nersesova L S, Gazaryants M G, Meliksetyan G O, Malakyan M G, Bajinyan S A, Akopian J I

出版信息

Radiats Biol Radioecol. 2015 Nov-Dec;55(6):625-31.

Abstract

The research deals with the effect of low-intensity 900 MHz frequency electromagnetic radiation (EMR), power density 25 μW/cm2, on the following rat brain and blood serum enzyme activities: creatine kinase (CK), playing a central role in the process of storing and distributing the cell energy, as well as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) that play a key role in providing the conjunction of carbohydrate and amino acid metabolism. The comparative analysis of the changes in the enzyme activity studied at different times following the two-hour single, as well as fractional, radiation equivalent of the total time showed that the most radiosensitive enzyme is the brain creatine kinase, which may then be recommended as a marker of the radio frequency radiation impact. According to the analysis of the changing dynamics of the CK, ALT and AST activity level, with time these changes acquire the adaptive character and are directed to compensate the damaged cell energy metabolism.

摘要

该研究探讨了功率密度为25μW/cm²的低强度900MHz频率电磁辐射(EMR)对大鼠以下脑和血清酶活性的影响:肌酸激酶(CK),在细胞能量储存和分配过程中起核心作用;以及丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST),它们在碳水化合物和氨基酸代谢的结合中起关键作用。对单次两小时辐射以及总时间的分次辐射当量后不同时间所研究的酶活性变化进行的比较分析表明,最具放射敏感性的酶是脑肌酸激酶,因此可将其推荐为射频辐射影响的标志物。根据对CK、ALT和AST活性水平变化动态的分析,随着时间推移,这些变化具有适应性特征,旨在补偿受损的细胞能量代谢。

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