Orgován Gábor, Noszál Béla
Acta Pharm Hung. 2015;85(4):123-9.
Resveratrol is a polyphenol that can be found in various plants, including grapes. Wines therefore also contain this compound. The famous phenomenon, named "French paradox" is considered to be an effect of resveratrol: the regular, modest consumption of red wine causes low incidence of cardiovascular diseases. Resveratrol is also reported to have anti-carcinogenic, anti-inflammatory, neuroprotective, and several further beneficial effects. As yet, resveratrol is not a registered drug in Hungary; nevertheless it is a common food supplement. Paradoxically, this is the very danger of its use: it can have harmful side-effects with several drugs. The bioavailability of resveratrol is, however, not favorable, due to its poor water-solubility and extensive metabolism. Our current knowledge is still far from being sufficient to understand its mode of action at a molecular level. Only a few of the most important physicochemical properties has been determined so far. The two major directions of pharmaceutical research of resveratrol are the elaboration of formulation systems that can improve the water solubility; the other is the development of analogous agents of enhanced effects.
白藜芦醇是一种存在于包括葡萄在内的多种植物中的多酚。因此葡萄酒中也含有这种化合物。著名的“法国悖论”现象被认为是白藜芦醇的一种作用：经常适量饮用红酒会使心血管疾病的发病率较低。据报道，白藜芦醇还具有抗癌、抗炎、神经保护以及其他多种有益作用。目前，白藜芦醇在匈牙利还不是一种注册药物；不过它是一种常见的食品补充剂。矛盾的是，这正是其使用的危险所在：它可能与多种药物产生有害的副作用。然而，由于白藜芦醇的水溶性差和广泛的代谢，其生物利用度并不理想。我们目前的知识仍远远不足以在分子水平上理解其作用方式。到目前为止，仅确定了少数几个最重要的物理化学性质。白藜芦醇药物研究的两个主要方向是开发能够提高水溶性的制剂系统；另一个是开发效果增强的类似物。
