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[白藜芦醇——抗癌活性评估]

[Resveratrol--evaluation of anticancer activity].

作者信息

Szumiło Justyna

机构信息

Akademia Medyczna w Lublinie, Katedra i Zakład Patomorfologii Klinicznej.

出版信息

Pol Merkur Lekarski. 2006 Mar;20(117):362-4.

Abstract

Resveratrol (3, 4',5-trihydroxystilbene) is a natural polyphenol isolated from many plants widely used in human diet e.g. in grapes and red wine. Many experimental studies have revealed the resveratrol ability to interfere with all the stages of carcinogenesis to suppress growth of many chemical-induced and spontaneous tumors in normal and transgenic rodents. Furthermore, the substance inhibited local growth and dissemination of some transplantable tumors in laboratory animals. Due to its valuable biological properties and lack of significant side effects after long-term administration it seems that resveratrol is one of the most promising agent which could be applied in the feature in cancer prevention and therapy in humans.

摘要

白藜芦醇(3,4',5-三羟基茋)是一种从许多植物中分离出的天然多酚,广泛存在于人类饮食中,如葡萄和红酒。许多实验研究表明,白藜芦醇能够干扰致癌作用的各个阶段,从而抑制正常和转基因啮齿动物中多种化学诱导和自发肿瘤的生长。此外,该物质还能抑制实验动物体内一些可移植肿瘤的局部生长和扩散。由于其具有宝贵的生物学特性,且长期给药后无明显副作用,白藜芦醇似乎是未来可应用于人类癌症预防和治疗的最有前景的药物之一。

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