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术中高场强磁共振成像可使脑室内中枢神经细胞瘤手术的切除范围最大化。

Intraoperative high-field MRI maximizes the extent of resection in intraventricular central neurocytoma surgery.

作者信息

Zhang Hui, Ma Li, Wang Qun, Zheng Xuan, Xue Zhe, Chen Xiao-Lei, Yu Xin-Guang, Wu Chen, Xu Bai-Nan, Sun Zheng-Hui

机构信息

Department of Neurosurgery, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China; Department of Neurosurgery, Air Force General Hospital of the Chinese PLA, Haidian District, Beijing, China.

Department of Anesthesiology, Beijing Military General Hospital, Beijing, China.

出版信息

J Clin Neurosci. 2016 Jun;28:47-54. doi: 10.1016/j.jocn.2015.08.045. Epub 2016 Mar 7.

Abstract

Central neurocytoma (CN) is a rare benign neuronal tumor of the ventricular system. Microsurgical resection is considered to be the mainstay of treatment for intraventricular CN, and the extent of resection is the most important prognostic factor. We describe our initial experience in the management of intraventricular CN with intraoperative MRI together with microscope-based neuronavigation. During a 5year period between February 2009 and June 2014, 18 consecutive patients with histologically proven CN were included in this study. Gross total tumor resection was achieved in 88.9% (16/18) of patients. There were no perioperative deaths, and the overall complication rate was 61.1% (11/18). The Karnofsky Performance Status score at the last follow-up was 100 in eight (44.4%), 90 in seven (38.9%), and ⩽70 in three patients (16.7%). We conclude that intraoperative high-field MRI combined with microscope-based neuronavigation can maximize the extent of resection in intraventricular CN surgery and minimize the risks of neurological impairment.

摘要

中枢神经细胞瘤(CN)是一种罕见的脑室系统良性神经元肿瘤。显微手术切除被认为是治疗脑室内CN的主要方法,切除范围是最重要的预后因素。我们描述了我们在术中MRI联合基于显微镜的神经导航管理脑室内CN方面的初步经验。在2009年2月至2014年6月的5年期间,本研究纳入了18例经组织学证实为CN的连续患者。88.9%(16/18)的患者实现了肿瘤全切除。无围手术期死亡,总体并发症发生率为61.1%(11/18)。最后一次随访时,卡氏功能状态评分8例(44.4%)为100分,7例(38.9%)为90分,3例(16.7%)≤70分。我们得出结论,术中高场MRI联合基于显微镜的神经导航可以在脑室内CN手术中最大限度地扩大切除范围,并将神经损伤风险降至最低。

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