Roh Eun, Song Do Kyeong, Kim Min-Seon
Appeptite Regulation Laboratory, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea.
Department of Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Exp Mol Med. 2016 Mar 11;48(3):e216. doi: 10.1038/emm.2016.4.
Accumulated evidence from genetic animal models suggests that the brain, particularly the hypothalamus, has a key role in the homeostatic regulation of energy and glucose metabolism. The brain integrates multiple metabolic inputs from the periphery through nutrients, gut-derived satiety signals and adiposity-related hormones. The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. Highly coordinated interactions between the brain and peripheral metabolic organs are critical for the maintenance of energy and glucose homeostasis. Defective crosstalk between the brain and peripheral organs contributes to the development of obesity and type 2 diabetes. Here we comprehensively review the above topics, discussing the main findings related to the role of the brain in the homeostatic regulation of energy and glucose metabolism.
来自基因动物模型的累积证据表明，大脑，尤其是下丘脑，在能量和葡萄糖代谢的稳态调节中起着关键作用。大脑通过营养物质、肠道产生的饱腹感信号和与肥胖相关的激素整合来自外周的多种代谢输入。大脑调节代谢的各个方面，如食物摄入、能量消耗、胰岛素分泌、肝脏葡萄糖生成以及脂肪组织和骨骼肌中的葡萄糖/脂肪酸代谢。大脑与外周代谢器官之间高度协调的相互作用对于维持能量和葡萄糖稳态至关重要。大脑与外周器官之间的串扰缺陷会导致肥胖和2型糖尿病的发生。在此，我们全面综述上述主题，讨论与大脑在能量和葡萄糖代谢稳态调节中的作用相关的主要发现。
