血清降钙素原、新蝶呤和γ干扰素在新生犊牛败血性大肠杆菌病中的诊断价值

Diagnostic value of serum procalcitonin, neopterin, and gamma interferon in neonatal calves with septicemic colibacillosis.

作者信息

Ercan Nazli, Tuzcu Nevin, Başbug Onur, Tuzcu Mehmet, Alim Ahmet

机构信息

Departments of Biochemistry (Ercan), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyInternal Medicine (Başbug), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyPathology (Tuzcu), Cumhuriyet University, Faculty of Veterinary Medicine, Sivas, TurkeyDepartment of Pharmaceutical Microbiology, Cumhuriyet University, Faculty of Pharmacy, Sivas, Turkey (Tuzcu, Alim)

出版信息

J Vet Diagn Invest. 2016 Mar;28(2):180-3. doi: 10.1177/1040638715626488.

DOI:10.1177/1040638715626488

PMID:26965240

Abstract

The objective of our study was to compare the serum concentrations of procalcitonin (PCT), neopterin, tumor necrosis factor alpha (TNF-α), prostaglandin E2, malondialdehyde, interleukin 8, and gamma interferon (IFN-γ) in neonatal calves with septicemic colibacillosis (n = 15) with healthy controls (n = 15). Septicemic colibacillosis was diagnosed based on clinical signs and the isolation of Escherichia coli from heparinized blood in clinically suspected cases. PCT, neopterin, TNF-α (p < 0.05), and IFN-γ concentrations in calves with septicemic colibacillosis were significantly higher than in the healthy controls (p < 0.01). Serum PCT concentrations were ~4 times higher in the calves with septicemic colibacillosis than in the healthy calves, suggesting that PCT could be a useful marker of septicemic colibacillosis in neonatal calves.

摘要

我们研究的目的是比较患败血性大肠杆菌病的新生犊牛（n = 15）与健康对照犊牛（n = 15）血清中降钙素原（PCT）、新蝶呤、肿瘤坏死因子α（TNF-α）、前列腺素E2、丙二醛、白细胞介素8和γ干扰素（IFN-γ）的浓度。根据临床症状以及在临床疑似病例中从肝素化血液中分离出大肠杆菌来诊断败血性大肠杆菌病。患败血性大肠杆菌病的犊牛中PCT、新蝶呤、TNF-α（p < 0.05）和IFN-γ的浓度显著高于健康对照犊牛（p < 0.01）。患败血性大肠杆菌病的犊牛血清PCT浓度比健康犊牛高约4倍，这表明PCT可能是新生犊牛败血性大肠杆菌病的一个有用标志物。