Drug Ther Bull. 2016 Mar;54(3):33-6. doi: 10.1136/dtb.2016.3.0390.
The QT interval is an important component of the electrocardiogram, which when prolonged can predict the risk of developing the potentially fatal cardiac arrhythmia, torsades de pointes. There is growing understanding of the genetics associated with cardiac arrhythmias and an increasing number of drugs that can prolong the QT interval. Consequently, assessment of the effect of drugs on the QT interval has become a significant aspect of drug development, regulatory assessment and clinical care. Here, we review the QT interval and the risks associated with drug-induced prolongation of the QT interval.
QT间期是心电图的一个重要组成部分，当QT间期延长时，可预测发生潜在致命性心律失常——尖端扭转型室速的风险。人们对与心律失常相关的遗传学的认识不断加深，且越来越多的药物可延长QT间期。因此，评估药物对QT间期的影响已成为药物研发、监管评估及临床护理的一个重要方面。在此，我们综述QT间期以及药物诱导的QT间期延长相关风险。
