Maruta K, Treichel U, Kolb-Bachofen V, Kolb H
Diabetes Research Institute, University of Duesseldorf, FRG.
Diabetes Res. 1989 Aug;11(4):173-6.
A prospective analysis of eosinophil counts in diabetes prone BB rats showed that eosinophilia (greater than 5%) occurred between 70-100 days of age. The presence of eosinophilia did not predict diabetes onset because persistently normoglycaemic animals developed eosinophilia as well. Nevertheless a correlation with the disease process in BB rats was found. Eosinophilia decreases a few weeks after diabetes onset but persists in non diabetic rats. Histological analyzes showed that eosinophilia correlates with eosinophil infiltration of islets (p less than 0.005) and the latter correlates with severe insulitis (p less than 0.005). These findings indicate that eosinophilia is associated with a late stage of islet inflammation in diabetes prone BB rats independent of whether the animals develop diabetes or not.
对糖尿病易感BB大鼠嗜酸性粒细胞计数的前瞻性分析表明，嗜酸性粒细胞增多（大于5%）出现在70至100日龄之间。嗜酸性粒细胞增多的出现并不能预测糖尿病的发病，因为血糖持续正常的动物也会出现嗜酸性粒细胞增多。然而，在BB大鼠中发现了与疾病进程的相关性。糖尿病发病几周后嗜酸性粒细胞增多会减少，但在非糖尿病大鼠中持续存在。组织学分析表明，嗜酸性粒细胞增多与胰岛嗜酸性粒细胞浸润相关（p小于0.005），而后者与严重胰岛炎相关（p小于0.005）。这些发现表明，嗜酸性粒细胞增多与糖尿病易感BB大鼠胰岛炎症的晚期有关，与动物是否患糖尿病无关。
