一项基于体素的形态计量学研究：正常衰老大脑中白质体积的年龄和性别相关变化
A voxel-based morphometric study of age- and sex-related changes in white matter volume in the normal aging brain.
作者信息
Liu Haijing, Wang Lixin, Geng Zuojun, Zhu Qingfeng, Song Zhenhu, Chang Ruiting, Lv Huandi
机构信息
Department of Radiology, Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
出版信息
Neuropsychiatr Dis Treat. 2016 Feb 24;12:453-65. doi: 10.2147/NDT.S90674. eCollection 2016.
OBJECTIVE
To carry out a cross-sectional study of 187 cognitively normal Chinese adults using the voxel-based morphometry (VBM) approach to delineate age-related changes in the white matter volume of regions of interest in the brain and further analyze their correlation with age.
MATERIALS AND METHODS
A total of 187 cognitively normal adults were divided into the young, middle, and old age-groups. Conventional magnetic resonance imaging was performed with the Achieva 3.0 T system. Structural images were processed using VBM8 and statistical parametric mapping 8. Regions of interest were obtained by WFU PickAtlas, and all realigned images were spatially normalized.
RESULTS
Females showed significantly greater total white matter volume than males (t=2.36, P=0.0096, false-discovery rate [FDR] corrected). VBM demonstrated statistically significant age-related differences in white matter volume between the young age-group and the middle age-group (P<0.05, FDR corrected) and between the middle age-group and the old age-group (P<0.05, FDR corrected). No interaction was found between age and sex on white matter volume (P<0.05, FDR corrected). Logistic regression analysis revealed nonlinear correlation between total white matter volume and age (R (2)=0.124, P<0.001). White matter volume gradually increased before 40 years of age, peaked around 50 years of age, and rapidly declined after 60 years of age.
CONCLUSION
Significant age-related differences are present in white matter volume across multiple brain regions during aging. The VBM approach may help differentiate underlying normal neurobiological aging changes of specific brain regions from neurodegenerative impairments.
目的
采用基于体素的形态学测量（VBM）方法，对187名认知正常的中国成年人进行横断面研究，以描绘大脑感兴趣区域白质体积的年龄相关变化，并进一步分析其与年龄的相关性。
材料与方法
将187名认知正常的成年人分为青年组、中年组和老年组。使用Achieva 3.0 T系统进行常规磁共振成像。结构图像采用VBM8和统计参数映射8进行处理。通过WFU PickAtlas获取感兴趣区域，并对所有重新对齐的图像进行空间归一化。
结果
女性的总白质体积显著大于男性（t=2.36，P=0.0096，经错误发现率[FDR]校正）。VBM显示，青年组与中年组之间（P<0.05，经FDR校正）以及中年组与老年组之间（P<0.05，经FDR校正）的白质体积存在统计学上显著的年龄相关差异。在白质体积方面，未发现年龄与性别之间存在交互作用（P<0.05，经FDR校正）。逻辑回归分析显示，总白质体积与年龄之间存在非线性相关性（R (2)=0.124，P<0.001）。白质体积在40岁之前逐渐增加，在50岁左右达到峰值，在60岁之后迅速下降。
结论
衰老过程中多个脑区的白质体积存在显著的年龄相关差异。VBM方法可能有助于区分特定脑区潜在的正常神经生物学衰老变化与神经退行性损伤。
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