Duan Yunyun, Liu Yaou, Liang Peipeng, Jia Xiuqin, Ye Jing, Dong Huiqing, Li Kuncheng
Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
Acta Radiol. 2014 Jun;55(5):589-93. doi: 10.1177/0284185113501815. Epub 2013 Aug 21.
Recent studies have shown that tissue damage in neuromyelitis optica (NMO) is not limited to the spinal cord and optic nerve but can also appear in the brain. Previous magnetic resonance imaging (MRI) studies have reported controversial findings regarding the presence of white matter atrophy in NMO patients.
To investigate regional white matter changes in NMO using voxel-based morphometry (VBM).
Conventional MRI and T1-weighted three-dimensional MRI were performed on 20 patients with NMO and 20 age- and sex-matched normal controls (NCs). The data were analyzed by statistical parametric mapping 5 (SPM5) to generate white matter concentration maps, and regional white matter concentrations were compared between the two groups. Relationships between the white matter concentration in regions with significant group differences and the Expanded Disability Status Scale (EDSS) and disease duration were further explored.
Compared to NCs, NMO patients had decreased white matter volumes in the right precentral gyrus, right postcentral gyrus, left middle and medial frontal gyrus, right superior frontal gyrus, bilateral inferior and superior parietal lobule, right angular gyrus, right middle occipital gyrus, and left precuneus. No significant correlation was found between white matter regions with volume reduction and the EDSS and disease duration in NMO.
We found white matter atrophy in several brain regions in the frontal, parietal, and occipital lobes in NMO, suggesting that subtle white matter damage relevant to the motor, vision, and cognition systems exists in NMO patients. The pattern of white matter atrophy in NMO is different from that in multiple sclerosis (MS).
最近的研究表明，视神经脊髓炎（NMO）中的组织损伤不仅限于脊髓和视神经，还可能出现在大脑中。先前的磁共振成像（MRI）研究报告了关于NMO患者白质萎缩存在的有争议的发现。
使用基于体素的形态计量学（VBM）研究NMO中的区域白质变化。
对20例NMO患者和20例年龄及性别匹配的正常对照（NCs）进行常规MRI和T1加权三维MRI检查。通过统计参数映射5（SPM5）分析数据以生成白质浓度图，并比较两组之间的区域白质浓度。进一步探讨两组间存在显著差异区域的白质浓度与扩展残疾状态量表（EDSS）和病程之间的关系。
与NCs相比，NMO患者在右侧中央前回、右侧中央后回、左侧额中回和额内侧回、右侧额上回、双侧顶下小叶和顶上小叶、右侧角回、右侧枕中回和左侧楔前叶的白质体积减少。NMO中白质体积减少的区域与EDSS和病程之间未发现显著相关性。
我们发现NMO患者额叶、顶叶和枕叶的几个脑区存在白质萎缩，这表明NMO患者存在与运动、视觉和认知系统相关的细微白质损伤。NMO的白质萎缩模式与多发性硬化症（MS）不同。
