Csomor Ján, Bunganič Bohuš, Zakharov Sergey, Pafčuga Igor, Sedloň Pavel, Urbánek Petr
Vnitr Lek. 2016 Jan;62(1):57-61.
Leylls syndrome (syndrome of toxic epidermal necrolysis) is a rare disease, firstly described by Scottish doctor of medicine Allan Lyell in 1956. It is characterized by huge skin and mucosa necrolysis, which affects at least 30 % of body surface, and systemic symptoms. According to the frequency of the occurrence it is an extremely rare condition, with an incidence of 0.5-2 cases per million residents per year. Leylls syndrome is considered as a toxoallergic reaction, triggered mostly by some medication and it is associated with a very high mortality rate (in the literature reported between 30 to 90 %). Adequate and timely local and systemic treatment at the Intensive Care Unit or at the specialized clinic can improve the overall poor prognosis of the patients. In our case report we describe a very rare case of the Lyells syndrome after exposure to the antifungal organosulfur compound, which is widely used by the homegardners and farmers.
莱尔综合征(中毒性表皮坏死松解症)是一种罕见疾病,由苏格兰医学博士艾伦·莱尔于1956年首次描述。其特征为大面积皮肤和黏膜坏死,累及至少30%的体表面积,并伴有全身症状。就发病频率而言,这是一种极为罕见的病症,每年每百万居民中的发病率为0.5至2例。莱尔综合征被认为是一种毒过敏反应,主要由某些药物引发,且与极高的死亡率相关(文献报道死亡率在30%至90%之间)。在重症监护病房或专科诊所进行充分及时的局部和全身治疗,可改善患者总体较差的预后。在我们的病例报告中,我们描述了一例接触抗真菌有机硫化合物后发生莱尔综合征的极为罕见病例,这种化合物被园艺爱好者和农民广泛使用。