Xin Tianchi, Greco Valentina, Myung Peggy
Department of Genetics, Yale School of Medicine, New Haven, Connecticut 06510, USA.
Department of Genetics, Yale School of Medicine, New Haven, Connecticut 06510, USA; Department of Dermatology, Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut 06510, USA; Department of Cell Biology, Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut 06510, USA; Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut 06510, USA.
Cell. 2016 Mar 10;164(6):1212-1225. doi: 10.1016/j.cell.2016.02.041.
Adult stem cells across diverse organs self-renew and differentiate to maintain tissue homeostasis. How stem cells receive input to preserve tissue structure and function largely relies on their communication with surrounding cellular and non-cellular elements. As such, how tissues are organized and patterned not only reflects organ function, but also inherently hardwires networks of communication between stem cells and their environment to direct tissue homeostasis and injury repair. This review highlights how different methods of stem cell communication reflect the unique organization and function of diverse tissues.
跨多种器官的成体干细胞自我更新并分化以维持组织稳态。干细胞如何接收输入信号以维持组织结构和功能,很大程度上依赖于它们与周围细胞和非细胞成分的通讯。因此,组织如何组织和形成模式不仅反映器官功能,而且内在地连接了干细胞与其环境之间的通讯网络,以指导组织稳态和损伤修复。本综述强调了干细胞通讯的不同方式如何反映不同组织的独特组织方式和功能。