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城市急诊部门中 HIV、乙型肝炎和丙型肝炎的选择退出小组检测:一项试点研究。

Opt-Out Panel Testing for HIV, Hepatitis B and Hepatitis C in an Urban Emergency Department: A Pilot Study.

机构信息

Department of Genito-Urinary Medicine and Infectious Disease, St James's Hospital, Dublin, Ireland.

Emergency Medicine Department, St James's Hospital, Dublin, Ireland.

出版信息

PLoS One. 2016 Mar 11;11(3):e0150546. doi: 10.1371/journal.pone.0150546. eCollection 2016.

Abstract

OBJECTIVES

Studies suggest 2 per 1000 people in Dublin are living with HIV, the level above which universal screening is advised. We aimed to assess the feasibility and acceptability of a universal opt-out HIV, Hepatitis B and Hepatitis C testing programme for Emergency Department patients and to describe the incidence and prevalence of blood-borne viruses in this population.

METHODS

An opt-out ED blood borne virus screening programme was piloted from March 2014 to January 2015. Patients undergoing blood sampling during routine clinical care were offered HIV 1&2 antibody/antigen assay, HBV surface antigen and HCV antibody tests. Linkage to care where necessary was co-ordinated by the study team. New diagnosis and prevalence rates were defined as the new cases per 1000 tested and number of positive tests per 1000 tested respectively.

RESULTS

Over 45 weeks of testing, of 10,000 patient visits, 8,839 individual patient samples were available for analysis following removal of duplicates. A sustained target uptake of >50% was obtained after week 3. 97(1.09%), 44(0.49%) and 447(5.05%) HIV, Hepatitis B and Hepatitis C tests were positive respectively. Of these, 7(0.08%), 20(0.22%) and 58(0.66%) were new diagnoses of HIV, Hepatitis B and Hepatitis C respectively. The new diagnosis rate for HIV, Hepatitis B and Hepatitis C was 0.8, 2.26 and 6.5 per 1000 and study prevalence for HIV, Hepatitis B and Hepatitis C was 11.0, 5.0 and 50.5 per 1000 respectively.

CONCLUSIONS

Opt-out blood borne viral screening was feasible and acceptable in an inner-city ED. Blood borne viral infections were prevalent in this population and newly diagnosed cases were diagnosed and linked to care. These results suggest widespread blood borne viral testing in differing clinical locations with differing population demographic risks may be warranted.

摘要

目的

研究表明,都柏林每 1000 人中就有 2 人感染艾滋病毒,超过这一水平就建议进行普遍筛查。我们旨在评估为急诊部患者实施普遍选择退出的艾滋病毒、乙型肝炎和丙型肝炎检测计划的可行性和可接受性,并描述该人群中血液传播病毒的发生率和流行率。

方法

从 2014 年 3 月到 2015 年 1 月,我们对选择退出的急诊部血液传播病毒筛查计划进行了试点。在常规临床护理过程中进行血液采样的患者被提供艾滋病毒 1&2 抗体/抗原检测、乙型肝炎表面抗原和丙型肝炎抗体检测。必要时,研究小组负责协调与护理的联系。新诊断和流行率的定义分别为每 1000 人检测的新病例数和每 1000 人检测的阳性病例数。

结果

在 45 周的检测中,在去除重复项后,有 10000 名患者就诊,有 8839 名患者的个体患者样本可供分析。在第 3 周后,目标参与率持续保持在 50%以上。艾滋病毒、乙型肝炎和丙型肝炎检测的阳性率分别为 97(1.09%)、44(0.49%)和 447(5.05%)。其中,艾滋病毒、乙型肝炎和丙型肝炎的新诊断病例分别为 7(0.08%)、20(0.22%)和 58(0.66%)。艾滋病毒、乙型肝炎和丙型肝炎的新诊断率分别为 0.8、2.26 和 6.5 例/1000 例,艾滋病毒、乙型肝炎和丙型肝炎的研究流行率分别为 11.0、5.0 和 50.5 例/1000 例。

结论

在市区急诊部,选择退出的血液传播病毒筛查是可行且可接受的。该人群中血液传播病毒感染较为普遍,新诊断病例得到诊断并与护理联系。这些结果表明,在不同临床地点和不同人群风险下,广泛进行血液传播病毒检测可能是必要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22ad/4788349/17f503fcc6db/pone.0150546.g001.jpg

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