Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
Imperial College Healthcare NHS Trust, London, UK.
HIV Med. 2018 Feb;19 Suppl 1:52-57. doi: 10.1111/hiv.12590.
The aims of this study were to to assess the feasibility of simultaneous testing for the blood-borne viruses (BBV), HIV, hepatitis C (HCV) and hepatitis B (HBV), in the Emergency Department (ED) and ascertain the seroprevalence for these three viruses in this setting.
A pilot BBV testing program was undertaken as part of routine clinical care in the ED. All ED attendees aged between 16 and 65 years old who were able to consent were tested over a 55 week period on an opt out basis. Patients with positive test results were linked to clinical services. Interventions aimed at improving testing rates were implemented and evaluated by quality improvement (QI) methodology.
Of 25,520 age-eligible ED attendees, 6108 (24%) underwent BBV testing; an additional 1160 (4.5%) underwent a standalone HIV test (total of 7268 (28%) individuals).There were 83/7268 (1.1%) non-negative (ie reactive or equivocal) results for HIV and 103/6108 (1.7%) and 32/6108 (0.52%) for anti-HCV IgG and HBsAg, respectively. Of these, 12 (0.17%), 16 (0.26%) and 8 (0.13%) were new reactive tests for HIV, HCV and HBV, respectively, which were able to be confirmed on a second test. Specific QI interventions led to temporary increases in testing rates.
An opt out BBV testing program in the ED is feasible and effective at finding new cases. However, the testing rate was low at 24%. Although QI interventions led to some improvement in testing rates, further studies are required to identify ways to achieve sustained increases in testing in this setting.
本研究旨在评估在急诊部(ED)同时检测血液传播病毒(BBV)、HIV、丙型肝炎(HCV)和乙型肝炎(HBV)的可行性,并确定该环境中这三种病毒的血清流行率。
作为 ED 常规临床护理的一部分,开展了一项试点 BBV 检测计划。在 55 周的时间内,对年龄在 16 至 65 岁之间、能够同意的所有 ED 就诊者进行了选择退出式检测。对阳性检测结果的患者进行了临床服务的联系。通过质量改进(QI)方法实施并评估了旨在提高检测率的干预措施。
在 25520 名符合年龄要求的 ED 就诊者中,有 6108 人(24%)接受了 BBV 检测;另有 1160 人(4.5%)接受了单独的 HIV 检测(共 7268 人(28%))。83/7268(1.1%)HIV 检测结果为非阴性(即阳性或可疑),103/6108(1.7%)和 32/6108(0.52%)分别为抗 HCV IgG 和 HBsAg。其中,12 例(0.17%)、16 例(0.26%)和 8 例(0.13%)为 HIV、HCV 和 HBV 的新阳性检测,均可在第二次检测中得到确认。具体的 QI 干预措施导致检测率暂时增加。
ED 选择退出式 BBV 检测计划是可行且有效的,可以发现新病例。然而,检测率仅为 24%。虽然 QI 干预措施导致检测率略有提高,但仍需要进一步研究,以确定在这种情况下持续提高检测率的方法。