Afzal Ayesha, Ajmal Khalida, Shakir Sabeen, Khan Bushra Tayabba, Ara Iffat
Department of Pharmacology, Wah Medical College, Wah Cantt, Pakistan.
Department of Pharmacology, Rawal Medical College, Rawalpindi, Pakistan.
J Pak Med Assoc. 2016 Mar;66(3):240-2.
To find out the possible effects of paroxetine on gastrointestinal smooth muscles in vitro as they can cause severe nausea and vomiting at the start of therapy which later settles down.
Power lab (USA) was used for recording the contractions of ileal smooth muscle of rabbits in response to acetylcholine, serotonin and paroxetine.
The percent responses with acetylcholine, serotonin and paroxetine were 100, 158.7 and 6.45 percent respectively indicating that acetylcholine and serotonin causes an increase in contractility of isolated ileal smooth muscle in comparison to paroxetine which has a depressant effect on motility.
Inability of paroxetine to enhance the serotonergic transmission in vitro causes a decrease in its qualitative response.
探究帕罗西汀对体外胃肠道平滑肌可能产生的影响，因为在治疗开始时它会引起严重的恶心和呕吐，不过这种症状随后会缓解。
使用美国的Power lab记录兔回肠平滑肌对乙酰胆碱、血清素和帕罗西汀的收缩反应。
乙酰胆碱、血清素和帕罗西汀的反应百分比分别为100%、158.7%和6.45%，这表明与对运动有抑制作用的帕罗西汀相比，乙酰胆碱和血清素会使离体回肠平滑肌的收缩力增加。
帕罗西汀在体外无法增强5-羟色胺能传递，导致其定性反应降低。
