Deslandre C
Service de pédiatrie générale, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France.
Arch Pediatr. 2016 Apr;23(4):437-41. doi: 10.1016/j.arcped.2016.01.005. Epub 2016 Mar 8.
Juvenile idiopathic arthritis (JIA) is a group of diseases defined by the presence of arthritis of more than 6 weeks duration in patients aged less than 16 years and with unknown etiology. The international classification based on clinical and biological criteria define each type of JIA: systemic, oligoarticular, polyarticular with and without rheumatoid factor, enthesitis-related arthritis, and psoriatic arthritis. However, some discussions persist concerning systemic-onset juvenile idiopathic arthritis, whose clinical symptoms and pathogenic mechanisms are quite similar to those observed in autoinflammatory diseases, arthritis with antinuclear factors (poly- and oligoarticular) that could be considered as a homogenous group, and a family history of psoriasis that frequently led to unclassified arthritis. Better knowledge of the pathogenic mechanisms should improve the initial clinical classification with more homogeneous groups of patients and reduce the number of unclassified cases of arthritis.
幼年特发性关节炎（JIA）是一组疾病，定义为年龄小于16岁、病程超过6周且病因不明的关节炎患者。基于临床和生物学标准的国际分类定义了每种类型的JIA：全身型、少关节型、伴或不伴类风湿因子的多关节型、附着点炎相关关节炎和银屑病关节炎。然而，关于全身型幼年特发性关节炎仍存在一些讨论，其临床症状和致病机制与自身炎症性疾病、可被视为同质组的抗核因子关节炎（多关节型和少关节型）以及常导致未分类关节炎的银屑病家族史中观察到的情况非常相似。更好地了解致病机制应能改善初始临床分类，使患者组更具同质性，并减少未分类关节炎病例的数量。
