Jalife José
Center for Arrhythmia Research, Cardiovascular Research Center, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.
Heart Fail Clin. 2016 Apr;12(2):309-22. doi: 10.1016/j.hfc.2015.08.024.
The mechanisms underlying atrial fibrillation (AF) in humans are poorly understood. In particular, we simply do not understand how atrial AF becomes persistent or permanent. The objective of this brief review is to address the most important factors involved in the mechanism of AF perpetuation, including structural remodeling in the form of fibrosis and electrical remodeling secondary to ion channel expression changes. In addition, I discuss the possibility that both fibrosis and electrical remodeling might be preventable when intervening pharmacologically early enough before the remodeling process reaches a point of no return.
人类心房颤动（AF）的潜在机制尚不清楚。特别是，我们根本不明白心房颤动如何变得持续或永久。本简要综述的目的是探讨房颤持续机制中涉及的最重要因素，包括纤维化形式的结构重塑以及离子通道表达变化继发的电重塑。此外，我还讨论了在重塑过程达到无法逆转的程度之前尽早进行药物干预时，纤维化和电重塑两者都可能被预防的可能性。
