Keng T M, Bucknall T E
Med J Malaysia. 1989 Jun;44(2):122-8.
The use of tissue adhesives has been widely studied since the 1960s. Since then they have found use in specialties like plastic surgery, neurosurgery, ENT surgery and dental surgery. Several papers have reported their safe use, both clinically and experimentally, particularly of the newer homologue n-butyl/2-cyanoacrylate (Histoacryl). In this study 43 patients (46 wounds) whose operations involved a groin incision were randomised into two groups for skin closure either with Dexon subcuticular suture (23 wounds) or Histoacryl glue (23 wounds). We found that both sets of wounds healed well with no wound infections or excessive inflammation when assessed at one week and four weeks. However the glued wounds had consistently better cosmesis scores (mean score 4.71 at four weeks) compared to the subcuticular Dexon wounds (mean score 4.00 at four weeks) and P value of less than 0.05. We feel that there is a place for tissue adhesives in skin closure for some general surgical wounds.
自20世纪60年代以来，组织粘合剂的使用就得到了广泛研究。从那时起，它们在整形外科、神经外科、耳鼻喉科手术和牙科手术等专业领域得到了应用。多篇论文报道了它们在临床和实验中的安全使用情况，特别是较新的同系物正丁基/2-氰基丙烯酸酯（组织粘合剂）。在本研究中，43例（46处伤口）手术涉及腹股沟切口的患者被随机分为两组，分别用涤纶皮下缝线（23处伤口）或组织粘合剂胶水（23处伤口）进行皮肤缝合。我们发现，在术后1周和4周评估时，两组伤口均愈合良好，无伤口感染或过度炎症。然而，与涤纶皮下缝线伤口（4周时平均评分为4.00）相比，使用胶水的伤口在美容评分方面始终更好（4周时平均评分为4.71），P值小于0.05。我们认为，对于一些普通外科伤口的皮肤缝合，组织粘合剂有其应用价值。
