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地塞米松通过调节小鼠体内的T细胞减轻棘球蚴病引起的过敏反应。

Dexamethasone attenuates echinococcosis-induced allergic reactions via regulatory T cells in mice.

作者信息

Zhang Qin, Ye Jianrong, Zheng Hong

机构信息

Department of Anaesthesiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, China.

出版信息

BMC Immunol. 2016 Mar 11;17:4. doi: 10.1186/s12865-016-0141-4.

DOI:10.1186/s12865-016-0141-4
PMID:26968945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4787038/
Abstract

BACKGROUND

Cystic echinococcosis (CE), caused by infection with Echinococcus granulosus larvae, is a potentially life-threatening disease in humans. Anaphylactic shock caused by CE is very dangerous, and is highly prevalent during surgery. Dexamethasone (DEX) is used clinically before operations to prevent allergic reactions; Regulatory T cells (Treg cells) are believed to be associated with negative immune response, which play an important role in alleviating allergic reactions. However, the association of Treg cells with DEX remains unknown.

METHODS

In this study, C57BL/6 mice were divided into uninfected group, untreated group and DEX group which were inoculated with protoscoleces from E. granulosus and sensitized using a cyst fluid suspension to induce anaphylactic shock. In addition, the mice in DEX group were treated with 10 mg/kg DEX by intraperitoneal injection 30 min before being sensitized.

RESULTS

It was found that 93.75 % of all sensitized mice experienced allergic symptoms. The levels of IgE, IgE/IgG, and IgE/IgG1 were significantly higher in both untreated group and DEX group. The proportion of CD4 + CD25 + FOXP3 + Treg cells relative to CD4+ Treg cells, and the levels of interleukin-10 (IL-10) and tumor growth factor-β (TGF-β1) were significantly higher in DEX group. The level of IL-13 was significantly higher in the sensitized mice than in the other groups. These cells may play a key role in alleviating the immune response in CE-induced anaphylactic shock.

CONCLUSIONS

The protective effect of DEX may be due to Treg cell upregulating IL-10 and TGF-β1 levels, and inhibiting helper T cell 2 cytokines.

摘要

背景

囊型包虫病（CE）由细粒棘球绦虫幼虫感染引起，是一种对人类有潜在生命威胁的疾病。CE引起的过敏性休克非常危险，在手术期间高度常见。地塞米松（DEX）在临床上用于术前预防过敏反应；调节性T细胞（Treg细胞）被认为与负性免疫反应相关，在减轻过敏反应中起重要作用。然而，Treg细胞与DEX之间的关联尚不清楚。

方法

在本研究中，将C57BL/6小鼠分为未感染组、未治疗组和DEX组，给它们接种细粒棘球绦虫原头节并用囊液悬液致敏以诱导过敏性休克。此外，DEX组小鼠在致敏前30分钟腹腔注射10mg/kg DEX进行治疗。

结果

发现所有致敏小鼠中有93.75%出现过敏症状。未治疗组和DEX组的IgE、IgE/IgG以及IgE/IgG1水平均显著更高。DEX组中CD4+CD25+FOXP3+Treg细胞相对于CD4+Treg细胞的比例以及白细胞介素-10（IL-10）和肿瘤生长因子-β（TGF-β1）水平显著更高。致敏小鼠中的IL-13水平显著高于其他组。这些细胞可能在减轻CE诱导的过敏性休克中的免疫反应中起关键作用。

结论

DEX的保护作用可能是由于Treg细胞上调IL-10和TGF-β1水平，并抑制辅助性T细胞2细胞因子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e703/4787038/00e29b982c5e/12865_2016_141_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e703/4787038/0f5949ae3b08/12865_2016_141_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e703/4787038/a827d68ec628/12865_2016_141_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e703/4787038/80b6b601a32f/12865_2016_141_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e703/4787038/cb4f60832954/12865_2016_141_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e703/4787038/00e29b982c5e/12865_2016_141_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e703/4787038/0f5949ae3b08/12865_2016_141_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e703/4787038/a827d68ec628/12865_2016_141_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e703/4787038/80b6b601a32f/12865_2016_141_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e703/4787038/cb4f60832954/12865_2016_141_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e703/4787038/00e29b982c5e/12865_2016_141_Fig5_HTML.jpg

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2
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Int J Parasitol. 2015 Feb;45(2-3):161-6. doi: 10.1016/j.ijpara.2014.10.005. Epub 2014 Dec 3.
3
Th17 cells are associated with the Th1/Th2‑cell balance during Echinococcus multilocularis infection.
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Parasit Vectors. 2021 Jun 3;14(1):295. doi: 10.1186/s13071-021-04795-2.
4
Identification of protective postexposure mycobacterial vaccine antigens using an immunosuppression-based reactivation model in the zebrafish.利用基于免疫抑制的斑马鱼再激活模型鉴定保护性结核疫苗抗原。
Dis Model Mech. 2018 Mar 13;11(3):dmm033175. doi: 10.1242/dmm.033175.
在多房棘球绦虫感染期间，辅助性T细胞17（Th17细胞）与Th1/Th2细胞平衡相关。
Mol Med Rep. 2014 Jul;10(1):236-40. doi: 10.3892/mmr.2014.2170. Epub 2014 Apr 24.
4
Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression by dexamethasone.丝裂原活化蛋白激酶（MAPK）磷酸酶 DUSP1 在炎症基因表达的反馈控制中的作用及其对地塞米松的抑制作用。
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5
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6
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7
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10
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