Nakagawa Masato, Karagiannis Peter, Yamanaka Shinya
Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.
EMBO J. 2016 Apr 15;35(8):801-2. doi: 10.15252/embj.201694095. Epub 2016 Mar 10.
Myc is one of the original reprogramming factors used to produce induced pluripotent stem cells. However, it is not necessary, instead its main role is to increase the efficiency of the reprogramming. The article by Scognamiglio (2016) helps clarify how. The authors show that Myc depletion leads to a reversible dormant state consistent with diapause. In this state, the cell sees its proliferation potential diminished but its pluripotency unchanged. The ability to coordinate the induction of this state should have important implications in cell differentiation.
Myc是用于产生诱导多能干细胞的原始重编程因子之一。然而，它并非必不可少，相反，其主要作用是提高重编程效率。斯科尼亚米廖（2016年）的文章有助于阐明其中的原理。作者表明，Myc缺失会导致一种与滞育一致的可逆休眠状态。在这种状态下，细胞的增殖潜能降低，但其多能性不变。调控这种状态诱导的能力在细胞分化中应具有重要意义。
