Centromere separation and aneuploidy: a lesson from multicentric chromosomes.

Premature centromere separation somehow nullifies the deposition of kinetochore proteins in multicentric chromosomes, is associated with early DNA replication of the centromere and the pericentric region and results in a lack of functionality of the centromere. It is conceivable that monocentric chromosomes which show premature separation, like the X chromosome as found in elderly human females (Fitzgerald et al, 1975), may have similar properties which result in a failure of centromere function and, hence, aneuploidy. This may be one of the general mechanisms by which chromosomes malsegregate.