伴有针对多种抗原的免疫球蛋白（Ig）G和IgA抗体的副肿瘤性天疱疮病例。
Case of paraneoplastic pemphigus with immunoglobulin (Ig)G and IgA antibodies to various antigens.
作者信息
Otsuka Yohei, Ueno Takashi, Yamase Aya, Ito Michiko, Osada Shinichi, Kawana Seiji, Funasaka Yoko, Teye Kwesi, Ishii Norito, Hashimoto Takashi, Saeki Hidehisa
机构信息
Department of Dermatology, Nippon Medical School, Tokyo, Japan.
Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan.
出版信息
J Dermatol. 2016 Aug;43(8):944-6. doi: 10.1111/1346-8138.13341. Epub 2016 Mar 11.
A 63-year-old Japanese man with non-Hodgkin B-cell lymphoma presented with erythematous skin lesions on his entire body, with oral, ocular and anal mucosal lesions. The patient was diagnosed with paraneoplastic pemphigus. Immunofluorescence showed both immunoglobulin (Ig)G and IgA antibodies to keratinocyte cell surfaces. Various immunoblot and enzyme-linked immunosorbent assays showed both IgG and IgA antibodies to various autoantigens, including desmogleins, desmocollins, envoplakin, periplakin and bullous pemphigoid antigens. This was a unique case with a very rare autoantibody profile in paraneoplastic pemphigus.
一名63岁的日本男性非霍奇金B细胞淋巴瘤患者全身出现红斑性皮肤病变，并伴有口腔、眼部和肛门黏膜病变。该患者被诊断为副肿瘤性天疱疮。免疫荧光显示针对角质形成细胞表面的免疫球蛋白（Ig）G和IgA抗体。各种免疫印迹和酶联免疫吸附测定显示针对多种自身抗原的IgG和IgA抗体，包括桥粒芯糖蛋白、桥粒胶蛋白、内披蛋白、周膜蛋白和大疱性类天疱疮抗原。这是一例副肿瘤性天疱疮中自身抗体谱非常罕见的独特病例。
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