层层相依：钙黏蛋白介导的细胞间连接中机械化学反馈及收缩性的形态发生作用
Pli Selon Pli: Mechanochemical Feedback and the Morphogenetic Role of Contractility at Cadherin Cell-Cell Junctions.
作者信息
Acharya Bipul R, Yap Alpha S
机构信息
Division of Cell Biology and Molecular Medicine, Program in Membrane Interface Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Division of Cell Biology and Molecular Medicine, Program in Membrane Interface Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
出版信息
Curr Top Dev Biol. 2016;117:631-46. doi: 10.1016/bs.ctdb.2015.10.021. Epub 2016 Jan 7.
Cellular contractility, driven by actomyosin networks coupled to cadherin cell-cell adhesion junctions, is a major determinant of cellular rearrangement during morphogenesis. It now emerges that contractility arises as the emergent property of a mechanochemical feedback system that encompasses the signals that regulate contractility and the elements of the actomyosin network itself.
由与钙黏蛋白细胞间黏附连接耦合的肌动球蛋白网络驱动的细胞收缩性，是形态发生过程中细胞重排的主要决定因素。现在发现，收缩性是一种机械化学反馈系统的涌现特性，该系统包含调节收缩性的信号和肌动球蛋白网络本身的元件。
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