Tang Vivian W
Department of Cell and Developmental Biology, University of Illinois, Urbana-Champaign, IL, 61801, USA.
F1000Res. 2018 Sep 25;7. doi: 10.12688/f1000research.15860.1. eCollection 2018.
The epithelial lateral membrane plays a central role in the integration of intercellular signals and, by doing so, is a principal determinant in the emerging properties of epithelial tissues. Mechanical force, when applied to the lateral cell-cell interface, can modulate the strength of adhesion and influence intercellular dynamics. Yet the relationship between mechanical force and epithelial cell behavior is complex and not completely understood. This commentary aims to provide an investigative look at the usage of cellular forces at the epithelial cell-cell adhesion interface.
上皮侧膜在细胞间信号整合中起核心作用，通过这种方式，它是上皮组织新出现特性的主要决定因素。当机械力作用于细胞间侧界面时，可调节黏附强度并影响细胞间动态变化。然而，机械力与上皮细胞行为之间的关系很复杂，尚未完全被理解。本评论旨在对上上皮细胞间黏附界面处细胞力的应用进行探索性研究。
