College of Pharmacy, Korea University, 2511 Sejongro, Sejong 339-700, Republic of Korea.
Center for Theragnosis, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Sungbuk-gu, Seoul 136-791, Republic of Korea; Department of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Republic of Korea.
J Control Release. 2016 Apr 28;228:141-149. doi: 10.1016/j.jconrel.2016.03.009. Epub 2016 Mar 10.
A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer.
采用包含金纳米粒子（NPs）和阿霉素（DOX）的核/壳纳米粒子（NPs）进行放化疗联合治疗。核/壳 NPs 中的金 NPs 被用作放射增敏剂。为了研究核/壳 NPs 的形态和粒径分布，使用了透射电子显微镜和动态光散射。还观察了体外释放行为、细胞摄取和毒性，以验证核/壳 NPs 作为纳米载体的功能。为了证明核/壳 NPs 在联合治疗中优于传统金 NPs 的优势，我们使用生物分布评估了核/壳 NPs 在肿瘤部位的积累行为。观察有无辐射的抗肿瘤疗效，以评估金 NPs 作为放射增敏剂的作用。
