三种单端孢霉烯族毒素在白色念珠菌感染家蚕试验中的治疗效果。
Therapeutic effects of three trichothecenes in the silkworm infection assay with Candida albicans.
作者信息
Uchida Ryuji, Namiguchi Shingo, Ishijima Hiroyuki, Tomoda Hiroshi
机构信息
Graduate School of Pharmaceutical Sciences, Kitasato University.
出版信息
Drug Discov Ther. 2016 Feb;10(1):44-8. doi: 10.5582/ddt.2016.01013.
The silkworm infection assay is a useful method for directly evaluating the in vivo therapeutic effects of drug candidates. In the present study, 3 known trichothecenes, trichodermin, epiisororidin E, and verrucarin A, were evaluated as antifungal agents in the silkworm-Candida albicans assay. Trichodermin and epiisororidin E yielded effective therapeutic effects, while verrucarin A exhibited no efficacy in this assay system. These results strongly suggest that trichodermin and epiisororidin E are the lead compounds for developing a new antifungal agent.
家蚕感染试验是直接评估候选药物体内治疗效果的一种有用方法。在本研究中，三种已知的单端孢霉烯族毒素，即木霉菌素、表异蛇孢菌素E和疣孢菌素A，在家蚕-白色念珠菌试验中被评估为抗真菌剂。木霉菌素和表异蛇孢菌素E产生了有效的治疗效果，而疣孢菌素A在该试验系统中没有显示出疗效。这些结果有力地表明，木霉菌素和表异蛇孢菌素E是开发新型抗真菌剂的先导化合物。
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