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神经内分泌肿瘤的组织病理学：当前概念与新进展

Histopathology of NET: Current concepts and new developments.

作者信息

Schmitt Anja M, Blank Annika, Marinoni Ilaria, Komminoth Paul, Perren Aurel

机构信息

Institute of Pathology, University of Bern, Murtenstrasse 31, 3010, Bern, Switzerland.

Institute of Pathology, Triemli City Hospital, Birmensdorferstrasse 497, 8063, Zürich, Switzerland.

出版信息

Best Pract Res Clin Endocrinol Metab. 2016 Jan;30(1):33-43. doi: 10.1016/j.beem.2016.02.002. Epub 2016 Feb 26.

DOI:10.1016/j.beem.2016.02.002

PMID:26971842

Abstract

The diagnosis of neuroendocrine tumors is based on their histopathologic appearance and immunohistochemical profile. With the WHO 2010 classification formal staging and grading was introduced for gastro-entero-pancreatic NET, however, the nomenclature for lung neuroendocrine tumors still relies on the carcinoid term. In this review we also focus on the situation of neuroendocrine carcinoma of unknown primary, tissue biomarkers and actual controversies in the histopathology of NEN.

摘要

神经内分泌肿瘤的诊断基于其组织病理学表现和免疫组化特征。随着2010年世界卫生组织分类的推出，胃肠胰神经内分泌肿瘤引入了正式的分期和分级，然而，肺神经内分泌肿瘤的命名仍依赖于类癌这一术语。在本综述中，我们还将关注原发灶不明的神经内分泌癌的情况、组织生物标志物以及神经内分泌肿瘤组织病理学中的实际争议。