Howitt Brooke E, Kelly Paul, McCluggage W Glenn
Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.
Curr Oncol Rep. 2017 Sep;19(9):59. doi: 10.1007/s11912-017-0617-2.
Neuroendocrine tumours are uncommon or rare at all sites in the female genital tract. The 2014 World Health Organisation (WHO) Classification of neuroendocrine tumours of the endometrium, cervix, vagina and vulva has been updated with adoption of the terms low-grade neuroendocrine tumour and high-grade neuroendocrine carcinoma. In the endometrium and cervix, high-grade neoplasms are much more prevalent than low-grade and are more common in the cervix than the corpus. In the ovary, low-grade tumours are more common than high-grade carcinomas and the term carcinoid tumour is still used in WHO 2014. The term ovarian small-cell carcinoma of pulmonary type is included in WHO 2014 for a tumour which in other organs is termed high small-cell neuroendocrine carcinoma. Neuroendocrine tumours at various sites within the female genital tract often occur in association with other neoplasms and more uncommonly in pure form.
神经内分泌肿瘤在女性生殖道的所有部位均不常见或罕见。2014年世界卫生组织（WHO）对子宫内膜、宫颈、阴道和外阴神经内分泌肿瘤的分类进行了更新，采用了低级别神经内分泌肿瘤和高级别神经内分泌癌这两个术语。在子宫内膜和宫颈中，高级别肿瘤比低级别肿瘤更为普遍，且在宫颈比在宫体更常见。在卵巢中，低级别肿瘤比高级别癌更常见，2014年WHO分类仍使用类癌这一术语。2014年WHO分类中纳入了肺型卵巢小细胞癌这一术语，用于指在其他器官中被称为高级别小细胞神经内分泌癌的肿瘤。女性生殖道内不同部位的神经内分泌肿瘤常与其他肿瘤同时发生，以纯形式出现则更为罕见。
