Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; Department of Endocrinology, St. Vincent's Hospital, Sydney, NSW 2010, Australia; Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Department of Surgery, St. Vincent's Hospital, Sydney, NSW 2010, Australia.
Cell Metab. 2016 Apr 12;23(4):602-9. doi: 10.1016/j.cmet.2016.02.007. Epub 2016 Mar 10.
High abundance of brown adipose tissue (BAT) is linked to lower glycaemia in humans, leading to the belief that BAT may protect against diabetes. The relationship between BAT glucose utilization and systemic glucose homeostasis has not been defined. In this paper we have characterized glycaemic excursions and BAT thermogenic responses in human brown adipocytes, BAT explants, and healthy adults through supraclavicular temperature profiling, revealing their circadian coupling in vivo and in vitro, orchestrated by UCP1, GLUT4, and Rev-erbα biorhythms. Extent of glycated haemoglobin also correlated positively with environmental temperature among community-dwelling patients. These data uncover potential crosstalk between BAT and glucose regulatory pathways, evident on cellular, tissue, individual, and population levels, and provide impetus to search for BAT harnessing strategies for therapeutic purposes.
棕色脂肪组织（BAT）含量高与人类较低的血糖水平有关，这导致人们认为 BAT 可能对糖尿病有保护作用。然而，BAT 葡萄糖利用与全身葡萄糖稳态之间的关系尚未明确。在本文中，我们通过锁骨上温度描记法对人类棕色脂肪细胞、BAT 外植体和健康成年人的血糖波动和 BAT 产热反应进行了特征描述，揭示了它们在体内和体外的昼夜耦合，由 UCP1、GLUT4 和 Rev-erbα 生物节律协调。糖化血红蛋白的程度也与社区居住患者的环境温度呈正相关。这些数据揭示了 BAT 和葡萄糖调节途径之间潜在的串扰，这种串扰在细胞、组织、个体和人群水平上都很明显，并为寻找 BAT 利用策略以达到治疗目的提供了动力。
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