Negroiu Cristina Elena, Tudorașcu Iulia, Bezna Cristina Maria, Godeanu Sanziana, Diaconu Marina, Danoiu Raluca, Danoiu Suzana
Department of Pathophysiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
J Clin Med. 2024 Mar 28;13(7):1973. doi: 10.3390/jcm13071973.
With a dramatic increase in the number of obese and overweight people, there is a great need for new anti-obesity therapies. With the discovery of the functionality of brown adipose tissue in adults and the observation of beige fat cells among white fat cells, scientists are looking for substances and methods to increase the activity of these cells. We aimed to describe how scientists have concluded that brown adipose tissue is also present and active in adults, to describe where in the human body these deposits of brown adipose tissue are, to summarize the origin of both brown fat cells and beige fat cells, and, last but not least, to list some of the substances and methods classified as BAT promotion agents with their benefits and side effects. We summarized these findings based on the original literature and reviews in the field, emphasizing the discovery, function, and origins of brown adipose tissue, BAT promotion agents, and batokines. Only studies written in English and with a satisfying rating were identified from electronic searches of PubMed.
随着肥胖和超重人群数量的急剧增加，对新型抗肥胖疗法的需求极为迫切。随着成人棕色脂肪组织功能的发现以及白色脂肪细胞中米色脂肪细胞的观察，科学家们正在寻找增加这些细胞活性的物质和方法。我们旨在描述科学家如何得出成人也存在并活跃着棕色脂肪组织的结论，描述人体中这些棕色脂肪组织沉积物的位置，总结棕色脂肪细胞和米色脂肪细胞的起源，最后但同样重要的是，列出一些被归类为棕色脂肪组织促进剂的物质和方法及其益处和副作用。我们基于该领域的原始文献和综述总结了这些发现，重点阐述了棕色脂肪组织、棕色脂肪组织促进剂和褐色脂肪因子的发现、功能及起源。仅从PubMed的电子搜索中识别出用英文撰写且评级令人满意的研究。
